Dichloromethane → 5-chloromethyl-2-[2-cyclopentyl-1-(4-methanesulfonyl-phenyl)-ethyl]-1H-pyrrolo[2,3-b]pyridine

HRID 184325Notes

Reaction equation

HRID 184325 reaction equation
[CH:1]1([CH2:6][CH:7]([c:8]2[cH:9][cH:10][c:11]([S:14](=[O:15])(=[O:16])[CH3:17])[cH:12][cH:13]2)[c:18]2[cH:19][c:20]3[c:21]([n:22][cH:23][c:24]([CH2:26][OH:27])[cH:25]3)[nH:28]2)[CH2:2][CH2:3][CH2:4][CH2:5]1.[Cl:33][CH2:34][Cl:35].[S:29]([Cl:30])([Cl:31])=[O:32]>>[CH:1]1([CH2:6][CH:7]([c:8]2[cH:9][cH:10][c:11]([S:14](=[O:15])(=[O:16])[CH3:17])[cH:12][cH:13]2)[c:18]2[cH:19][c:20]3[c:21]([n:22][cH:23][c:24]([CH2:26][Cl:31])[cH:25]3)[nH:28]2)[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 24386Thionyl ChlorideHCID 53250433{2-[2-cyclopentyl-1-(4-methanesulfonyl-phenyl)-ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-methanol

Product 1

HCID 672294355-chloromethyl-2-[2-cyclopentyl-1-(4-methanesulfonyl-phenyl)-ethyl]-1H-pyrrolo[2,3-b]pyridine

Sources & evidence

ORD record
ord-4efae0b9a6fc42e4af99309ff7b75e75
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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