3-Bromobenzylmethylsulfone → N-(5-{3-[(methylsulfonyl)methyl]phenyl}-2,3-dihydro-1H-inden-2-yl)-2-propanesulfonamide
Reaction equation
CC1(C)C(C)(C)OB([C:9]2[CH:10]=[C:11]3[C:15](=[CH:16][CH:17]=2)[CH2:14][CH:13]([NH:18][S:19]([CH:22]([CH3:24])[CH3:23])(=[O:21])=[O:20])[CH2:12]3)O1.[CH3:26][S:27]([CH2:30][C:31]1[CH:36]=[CH:35][CH:34]=[C:33](Br)[CH:32]=1)(=[O:29])=[O:28]>>[CH3:26][S:27]([CH2:30][C:31]1[CH:32]=[C:33]([C:9]2[CH:10]=[C:11]3[C:15](=[CH:16][CH:17]=2)[CH2:14][CH:13]([NH:18][S:19]([CH:22]([CH3:23])[CH3:24])(=[O:20])=[O:21])[CH2:12]3)[CH:34]=[CH:35][CH:36]=1)(=[O:28])=[O:29]Participants
3
Procedure
The title compound was prepared from N-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide and (3-bromophenyl)methyl methyl sulfone in a similar manner to Example 16.
Sources & evidence
- ORD record
- ord-ebd0374d9b3b4a19b59120cc38343070
- Source dataset
- uspto-grants-2010_06
- Patent number
- US07741351B2
Reaction notes
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