Triethylamine → Lenalidomide

Participants

Reaction Conditions

Reaction Steps

The lenalidomide hydrochloride salt was suspended in methanol (350 ml) and 1.1 mole equivalent of triethylamine was slowly added whilst stirring. The reaction mixture was stirred at ambient temperature for the next 45 minutes and then cooled at 5-10° C. and maintained at the same temperature for the next 45 minutes. The precipitated solid was filtered and dried. It was then washed with methanol (105 ml) and the resultant lenalidomide isolated by filtration. The pure product was dried at 50-55° C. and 150-200 mmHg pressure for about 7-8 hours.

Provenance & Evidence