反应详情

450 mg (0.97 mmol) of 4-[1-(4-methoxybenzyl)-3-(3-nitrophenyl)-1H-pyrazol-4-yl]-2-(methylsulfonyl)pyrimidine were dissolved in a mixture of 10 ml of dioxane and 5 ml of ethylamine 70% in water. The resulting solution was submitted to microwave irradiation in a sealed vial at 140° C. for 45 minutes. The solvent was then removed and the residue was partitioned between dichloromethane and aqueous sodium hydrogenocarbonate. The organic phase was then dried over sodium sulphate and evaporated to dryness. 391 mg (94%) of the title compound were obtained by trituration with diethylether.

1. customirradiation in a sealed vial at 140° C. for 45 minutes
2. customThe solvent was then removed
3. customthe residue was partitioned between dichloromethane and aqueous sodium hydrogenocarbonate
4. dry with materialThe organic phase was then dried over sodium sulphate
5. customevaporated to dryness