HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 3-(2-(tert-butoxy)-2-oxoethoxy)benzoate → [3-(Methoxycarbonyl)phenoxy]acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 3-(2-(tert-butoxy)-2-oxoethoxy)benzoate | HCID 16094634 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Solvent | Anisole | HCID 7519 | — |
| Product | [3-(Methoxycarbonyl)phenoxy]acetic acid | HCID 13816150 | 86% |
Reaction Steps
A solution of t-butyl [3-(methoxycarbonyl)phenoxy]acetate in trifluoroacetic acid (1 kg), anisole (100 mL) and dichloromethane (1 L) was stirred at room temperature for 48 hours. The reaction mixture was concentrated and then the residue was crystallized from diisopropyl ether to obtain the title compound (467 g, 86%) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08946264B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-b38f9c98b5864a879d1efd653c9006d9 |
| Source note | uspto-grants-2015_02 |