4-(Benzyloxy)-2-methoxypyridine → HCID 178493525, compound

HRID 1843714Notes

Reaction equation

HRID 1843714 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][N:12]=[C:11]([O:15][CH3:16])[CH:10]=1)C1C=CC=CC=1.[H][H]>C(O)C.[C].[Pd]>[CH3:16][O:15][C:11]1[CH:10]=[C:9]([OH:8])[CH:14]=[CH:13][N:12]=1

Participants

5

Reactant 2

HCID 580537844-(Benzyloxy)-2-methoxypyridineHCID 178418361HCID 178418361, compound

Product 1

HCID 178493525HCID 178493525, compoundYield 99.9%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

A solution of 4-(benzyloxy)-2-methoxypyridine produced in Example (16a) (4.65 g, 21.6 mmol) and 10% palladium carbon (2.30 g, 2.16 mmol) in ethanol (100 mL) was stirred in a hydrogen atmosphere at room temperature for 30 minutes. The insoluble matter was separated by filtration and then the filtrate was concentrated to obtain the title compound (2.70 g, 99%) as a colorless oil.

Workup

  1. customThe insoluble matter was separated by filtration
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-f0ce62977f124c8392566d672993ed37
Source dataset
uspto-grants-2015_02
Patent number
US08946264B2

Reaction notes

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