HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → HCID 86661632, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 3-Bromo-5-hydroxypyridine | HCID 599529 | — |
| Reactant | tert-Butyl [(5-chloro-2-nitrophenyl)methyl]carbamate | HCID 71357443 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86661632 | HCID 86661632 | 99.9% |
Reaction Steps
The reaction and post-treatment were carried out according to Example (1a) using 5-bromo-3-hydroxypyridine (5.01 g, 28.8 mmol), tert-butyl (5-chloro-2-nitrophenyl)methylcarbamate (US200216506 A1, 7.50 g, 26.2 mmol), sodium hydride (63%, 1.10 g, 28.8 mmol) and DMF (87 mL) to obtain the title compound (11.1 g, 99%) as a yellow brown solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08946264B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-30f1849d2d02402e8168bc2bd16cb771 |
| Source note | uspto-grants-2015_02 |