Potassium Phosphate, Tribasic → HCID 66807344, compound

Participants

Reaction Steps

Using analogous reaction conditions as described in example 1, 7-(4-fluoro-phenyl)-3,4-dihydro-2H-isoquinolin-1-one (100 mg, 0.4132 mmol) was reacted with 3-iodo-4-methyl-pyridine (108.5 mg, 0.4958 mmol), 1,4-dioxane (25 mL), copper iodide (2.8 mg, 0.01432 mmol), trans-N,N′-dimethyl-cyclohexyl-1,2-diamine (14.2 mg, 0.1239 mmol) and potassium phosphate (219.2 mg, 1.0330 mmol) to afford the crude product. Purification by column chromatography on silica gel (2% methanol in CHCl3), followed by preparative HPLC afforded 15 mg of the product (11.1% yield).

Provenance & Evidence