HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2-Nitro-vinyl)-4-trifluoromethyl-benzene → 2-[4-(Trifluoromethyl)phenyl]ethan-1-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2-Nitro-vinyl)-4-trifluoromethyl-benzene | HCID 688231 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-[4-(Trifluoromethyl)phenyl]ethan-1-amine | HCID 1988106 | 96.77% |
Reaction Steps
Using analogous reaction conditions and workup as described in Example 1, step 2, 1-(2-nitro-vinyl)-4-trifluoromethyl-benzene (I-4a: 2.5 g, 11.52 mmol) was reacted with LAH (856 mg, 23.04 mmol) in dry THF (50 mL) to afford 2.1 g of the product (96.77%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08946260B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-521ad10f2ad44db2a25a869641004276 |
| Source note | uspto-grants-2015_02 |