Phosphorus oxide (P4O10) → 7-(Trifluoromethyl)-3,4-dihydroisoquinolin-1(2H)-one

Participants

Reaction Conditions

Reaction Steps

Using an analogous procedure and workup as described in Example 1, step 4, [2-(4-trifluoromethyl-phenyl)-ethyl]-carbamic acid ethyl ester (I-4-c: 700 mg, 2.68 mmol) in POCl3 (5 mL) was reacted with P2O5 (756 mg, 5.36 mmol). The resulting mixture was stirred at 105° C. for 2 hours to afford the crude product. Purification by column chromatography on silica gel (10% ethylacetate in hexane) afforded 120 mg of the product (20.83% yield).

Provenance & Evidence