Nitromethane → 3-(2-Nitroethenyl)thiophene

Participants

Reaction Conditions

Reaction Steps

Using an analogous reaction procedure and workup as described in Example 1, step 1, thiophene-3-carbaldehyde (3 g, 26.78 mmol) in ethanol (50 mL) was reacted with nitro methane (1.45 mL, 26.78 mmol) and 10N NaOH (3.5 mL, 28.11 mmol). The resulting mixture was stirred at 0° C. for 1.30 hours to afford 3 g of the product (72.28% yield).

Provenance & Evidence