反应详情

Using analogous reaction conditions as described in example 1, 5,6-dihydro-4H-thieno[2,3-c]pyridin-7-one (I-5d: 110 mg, 0.718 mmol) was reacted with 3-bromo-pyridine (136 mg, 0.861 mmol), 1,4-dioxane (5 mL), copper iodide (13.5 mg, 0.071 mmol), trans-N,N′-dimethyl-cyclohexyl-1,2-diamine (0.033 mL, 0.215 mmol) and potassium phosphate (456 mg, 2.15 mmol) to afford the crude product. Purification by column chromatography on silica gel (1% methanol in DCM) afforded 65 mg of the product (39.3% yield).

1. customreaction conditions
2. customto afford the crude product
3. customPurification by column chromatography on silica gel (1% methanol in DCM)