HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aluminium lithium hydride → 2-(1-Benzothiophen-2-yl)ethan-1-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Reactant | 2-(2-Nitroethenyl)-1-benzothiophene | HCID 66801639 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-(1-Benzothiophen-2-yl)ethan-1-amine | HCID 12666893 | 90.3% |
Reaction Steps
Using analogous reaction conditions and workup as described in Example 1, step 2, 2-(2-nitro-vinyl)-benzo[b]thiophene (I-9a: 2.1 g, 0.010 mol) in dry THF (30 mL) was reacted with LAH (0.81 g, 0.021 mol) in dry THF (20 mL) to afford 1.6 g of the product (87.91% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08946260B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-c0f4c3ad00464348aa8058b3b9ba2953 |
| Source note | uspto-grants-2015_02 |