Phosphorus oxide (P4O10) → HCID 12581538, compound

Participants

Reaction Conditions

Reaction Steps

Using an analogous procedure and workup as described in Example 1, step 4, (2-naphthalen-2-yl-ethyl)-carbamic acid ethyl ester (I-10c: 1.3 g, 5.349 mmol) in POCl3 (16 mL) was reacted with P2O5 (1.58 g, 11.205 mmol). The resulting mixture was stirred at 110° C. for 3 hours to afford the crude product. Purification by column chromatography on silica gel (20% ethylacetate in hexane) afforded 415 mg of the product (40% yield).

Provenance & Evidence