Potassium Phosphate, Tribasic → HCID 56942728, compound

Participants

Reaction Steps

Using analogous reaction conditions as described in Example 1, 3,4-dihydro-2H-benzo[h]isoquinolin-1-one (I-10d: 200 mg, 1.015 mmol) was reacted with 3-iodo-4-methyl-pyridine (266 mg, 1.214 mmol), 1,4-dioxane (15 mL), copper iodide (19 mg, 0.10 mmol), trans-N,N′-dimethyl-cyclohexyl-1,2-diamine (43 mg, 0.302 mmol) and potassium phosphate (538 mg, 2.53 mmol) to afford the crude product. Purification by column chromatography on silica gel (1% methanol in CHCl3) afforded 162 mg of the product (55.47% yield).

Provenance & Evidence