HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Methoxy--nitrostyrene → 3-Methoxyphenethylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Methoxy--nitrostyrene | HCID 261411 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-Methoxyphenethylamine | HCID 74866 | 73.3% |
Reaction Steps
Using analogous reaction conditions and workup as described in Example 1, step 2, 1-methoxy-3-(2-nitro-vinyl)-benzene (I-11a: 10.5 g, 58.659 mmol) in dry THF (110 mL) was reacted with LAH (6.68 g, 175.97 mmol) to afford 6.5 g of the product (73% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08946260B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-35b41d3331604e3388d0978fdce67f35 |
| Source note | uspto-grants-2015_02 |