Phosphorus oxide (P4O10) → 6-methoxy-3,4-dihydroisoquinolin-1(2H)-one

Participants

Reaction Conditions

Reaction Steps

Using an analogous procedure and workup as described in Example 1, step 4, [2-(3-methoxy-phenyl)-ethyl]-carbamic acid ethyl ester (I-11c: 6.2 g, 29.5238 mmol) in POCl3 (62 mL) was reacted with P2O5 (8.38 g, 59.047 mmol). The resulting mixture was stirred at 120° C. for 1 hour to afford the crude product. Purification by column chromatography on silica gel (2% methanol in DCM) afforded 0.400 g of the product (7.6% yield).

Provenance & Evidence