Phosphorus oxide (P4O10) → 2-Bromo-6,7-dihydrothieno[3,2-c]pyridin-4(5H)-one

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Reaction Steps

Using analogous reaction conditions and workup as described in example 1, step 4, [2-(5-bromo-thiophen-2-yl)-ethyl]-carbamic acid ethyl ester (I-14c: 2.7 g, 9.8 mmol) in POCl3 (20 mL) was reacted with P2O5 (2.7 g, 19.64 mmol) to afford the crude product. Purification by column chromatography on silica gel (0.5% methanol in DCM) afforded 850 mg of the product (37.56% yield).

Provenance & Evidence