Potassium Phosphate, Tribasic → HCID 89964535, compound

Participants

Reaction Steps

Using analogous reaction conditions as described in Example 1, 3-(4-fluoro-phenyl)-6,7-dihydro-5H-thieno[3,2-c]pyridin-4-one (I-15c: 150 mg, 0.61 mmol) was reacted with 3-iodo-4-methyl-pyridine (133 mg, 0.61 mmol), 1,4-dioxane (10 mL), copper iodide (11.6 mg, 0.061 mmol), trans-N,N′-dimethyl-cyclohexyl-1,2-diamine (25.98 mg, 0.183 mmol) and potassium phosphate (323.3 mg, 1.525 mmol) to afford the crude product. Purification by column chromatography on silica gel (1% methanol in CHCl3) afforded 35 mg of the product (17.5% yield).

Provenance & Evidence