4-(Trifluoromethyl)phenylacetonitrile → 2-[4-(Trifluoromethyl)phenyl]ethan-1-amine

Participants

Reaction Steps

(4-Trifluoromethyl-phenyl)-acetonitrile (2 g, 10.81 mmol) in methanolic ammonia (50 mL) was added to Raney nickel (400 mg) in methanol taken in a parr hydrogenator. The flask was stirred at 50 PSI overnight. The reaction was monitored by TLC (10% methanol in CHCl3). The reaction mixture was filtered through celite bed and the filtrate was dried under reduced pressure to afford 2 g of the product (97.89% yield).

Provenance & Evidence