Potassium Phosphate, Tribasic → HCID 56942732, compound

Participants

Reaction Steps

Using analogous reaction conditions as described in Example 1, 6-trifluoromethyl-3,4-dihydro-2H-isoquinolin-1-one (I-17c: 150 mg, 0.698 mmol) was reacted with 3-iodo-4-methyl-pyridine (152.8 mg, 0.698 mmol), 1,4-dioxane (10 mL), copper iodide (13.3 mg, 0.0698 mmol), trans-N,N′-dimethyl-cyclohexyl-1,2-diamine (29.73 mg, 0.209 mmol) and potassium phosphate (369.94 mg, 1.745 mmol) to afford the crude product. Purification by column chromatography on silica gel (1.5% methanol in DCM) afforded 20 mg of the product (9.38% yield).

Provenance & Evidence