Potassium Phosphate, Tribasic → 7-Trifluoromethyl-3,4-dihydro-[2,4']biisoquinolinyl-1-one

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Reaktionsschritte

Using analogous reaction conditions as described in Example 1, 7-trifluoromethyl-3,4-dihydro-2H-isoquinolin-1-one (I-16c: 150 mg, 0.698 mmol) was reacted with 4-bromo-isoquinoline (145 mg, 0.698 mmol), 1,4-dioxane (10 mL), copper iodide (13.29 mg, 0.0698 mmol), trans-N,N′-dimethyl-cyclohexyl-1,2-diamine (29.74 mg, 0.209 mmol) and potassium phosphate (369.94 mg, 1.745 mmol) to afford the crude product. Purification by column chromatography on silica gel (1.5% methanol in DCM) afforded 25 mg of the product (10.50% yield).

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