2-Methyl-2-(4-(trifluoromethyl)phenyl)propanenitrile → 2-Methyl-2-[4-(trifluoromethyl)phenyl]propan-1-amine

HRID 1843872Notes

Reaction equation

HRID 1843872 reaction equation
[CH3:1][C:2]([C:6]1[CH:11]=[CH:10][C:9]([C:12]([F:15])([F:14])[F:13])=[CH:8][CH:7]=1)([CH3:5])[C:3]#[N:4]>N.[Ni]>[CH3:5][C:2]([C:6]1[CH:11]=[CH:10][C:9]([C:12]([F:13])([F:15])[F:14])=[CH:8][CH:7]=1)([CH3:1])[CH2:3][NH2:4]

Participants

4

Reactant 1

HCID 102199882-Methyl-2-(4-(trifluoromethyl)phenyl)propanenitrile

Product 1

HCID 288754122-Methyl-2-[4-(trifluoromethyl)phenyl]propan-1-amineYield 106.2%

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 222AmmoniaSolvent

Procedure

Using analogous reaction conditions as described in Example 16, step 1, 2-methyl-2-(4-trifluoromethyl-phenyl)-propionitrile (I-20a: 1.2 g, 5.6338 mmol) in methanolic ammonia (10 mL) was reacted with to Raney nickel (200 mg) to afford 1.3 g of the crude product which was used in the next step without further purification.

Workup

  1. customreaction conditions

Sources & evidence

ORD record
ord-25c91c1e42994703a67cf30611acc365
Source dataset
uspto-grants-2015_02
Patent number
US08946260B2

Reaction notes

Loading…