Potassium Phosphate, Tribasic → HCID 66807306, compound

Participants

Reaction Steps

Using analogous reaction conditions as described in Example 1, 4,4-dimethyl-7-trifluoromethyl-3,4-dihydro-2H-isoquinolin-1-one (I-20d: 200 mg, 0.8230 mmol) was reacted with 3-bromo-4-methyl-pyridine (91.9 mL, 0.8230 mmol), 1,4-dioxane (3 mL), copper iodide (15.6 mg, 0.0823 mmol), trans-N,N′-dimethyl-cyclohexyl-1,2-diamine (38.8 mL, 0.2469 mmol) and potassium phosphate (436.1 mg, 2.0575 mmol) to afford the crude product. Purification by column chromatography on silica gel (50% ethylacetate in hexane) afforded 15 mg of the product (5.44% yield).

Provenance & Evidence