HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 2-(Trifluoromethyl)phenethylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 2-(Trifluoromethyl)phenylacetonitrile | HCID 76435 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Ammonia | HCID 222 | — |
| Product | 2-(Trifluoromethyl)phenethylamine | HCID 69883 | 44.9% |
Reaction Steps
Using analogous reaction conditions as described in Example 16, step 1, (2-trifluoromethyl-phenyl)-acetonitrile (I-22a: 2.4 g) in methanolic ammonia (10 mL) was reacted with Raney nickel (5 g) and methanol (30 mL) to afford 1.1 g of the product (44% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08946260B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-1a67377c88334ab9adbbae5501ab3a46 |
| Source note | uspto-grants-2015_02 |