Phosphorus oxide (P4O10) → HCID 66807412, compound

Participants

Reaction Conditions

Reaction Steps

Using the same procedure and workup as described in Example 1, step 4, [2-(2-trifluoromethyl-phenyl)-ethyl]-carbamic acid ethyl ester (I-22c: 1.2 g, 4.5977 mmol) in POCl3 (13 mL) was reacted with P2O5 (1.3 g, 9.195 mmol). The resulting mixture was stirred at 115° C. for 2 hours to afford the crude product. Purification by column chromatography on silica gel (60% ethylacetate in hexane) afforded 0.090 g of the product (9.1% yield).

Provenance & Evidence