Potassium Phosphate, Tribasic → HCID 66803663, compound

Participants

Reaction Steps

Using analogous reaction conditions as described in Example 1, 5-trifluoromethyl-3,4-dihydro-2H-isoquinolin-1-one (I-22d: 0.090 g, 0.4186 mmol) was reacted with 3-iodo-4-methyl-pyridine (0.091 g, 0.4186 mmol), 1,4-dioxane (10 mL), copper iodide (0.007 g, 0.04186 mmol), trans-N,N′-dimethyl-cyclohexyl-1,2-diamine (0.017 g, 0.1255 mmol) and potassium phosphate (0.221 g, 1.0465 mmol) to afford the crude product. Purification by column chromatography on silica gel (60% ethylacetate in hexane) afforded 0.031 g of the product (24% yield).

Provenance & Evidence