Cyclopropanecarbonyl chloride → HCID 89968212, compound

Participants

Reaction Steps

Using analogous reaction conditions as described in Example 24, 7-amino-2-(4-methyl-pyridin-3-yl)-3,4-dihydro-2H-isoquinolin-1-one (I-25a: 100 mg, 0.3533 mmol) in THF (5 mL) was reacted with cyclopropanecarbonyl chloride (35.5 mL, 0.3886 mmol) and TEA (74.4 mL, 0.5299 mmol) to afford the crude product. Purification by column chromatography on silica gel (80% ethylacetate in hexane), followed by preparative HPLC afforded 16 mg of the product (14% yield).

Provenance & Evidence