反应详情

1M solution of boran tri-bromide in DCM (0.839 mL, 0.839 mmol) was added to a stirred solution of 7-methoxy-2-(4-methyl-pyridin-3-yl)-3,4-dihydro-2H-isoquinolin-1-one (26A: 90 mg, 0.335 mmol) in DCM (3 mL) at 0° C. The resulting mixture was stirred at room temperature for 3 hours. The reaction was monitored by TLC (5% methanol in DCM). The reaction mixture was quenched with chilled water and extracted with DCM. The organic layer was washed with NaHCO3 solution, brine solution, dried over Na2SO4 and concentrated. Purification by column chromatography on silica gel (3% methanol in DCM) afforded 40 mg of the product (47% yield).

1. customThe reaction mixture was quenched with chilled water
2. extractionextracted with DCM
3. washThe organic layer was washed with NaHCO3 solution, brine solution
4. dry with materialdried over Na2SO4
5. concentrationconcentrated
6. customPurification by column chromatography on silica gel (3% methanol in DCM)