8-Hydroxyquinoline → HCID 66807415, compound

Participants

Reaction Steps

Using analogous reaction conditions as described in Example 1, 7-trifluoromethyl-2H-isoquinolin-1-one (I-29d: 0.15 g, 0.0007 mol) was reacted with 3-iodo-4-methyl-pyridine (0.185 g, 0.8 mmol), DMSO (30 mL), copper iodide (0.026 g, 0.00014 mol), quinolin-8-ol (0.02 g, 0.14 mmol) and potassium carbonate (0.126 g, 0.9 mmol) to afford the crude product. Purification by column chromatography on silica gel (8% ethylacetate in hexane) afforded 0.055 g of the product (23.8% yield).

Provenance & Evidence