Potassium Phosphate, Tribasic → HCID 66804016, compound

Participants

Reaction Steps

Using analogous reaction conditions as described in Example 1, 7-nitro-3,4-dihydro-2H-isoquinolin-1-one (I-24a: 600 mg, 3.125 mmol) was reacted with 3-iodo-4-methyl-pyridine (684.3 mg, 3.125 mmol), 1,4-dioxane (10 mL), copper iodide (59.5 mg, 0.3125 mmol), trans-N,N′-dimethyl-cyclohexyl-1,2-diamine (147.5 mL, 0.9375 mmol) and potassium phosphate (1.65 g, 7.8125 mmol) to afford the crude product. Purification by column chromatography on silica gel (50% ethylacetate in hexane) afforded 150 mg of the product (17% yield).

Provenance & Evidence