Nitromethane → 2-Chloro-1-fluoro-4-(2-nitro-vinyl)-benzene

Participants

Reaction Steps

Using the same reaction procedure and workup as described in Example 1, 3-chloro-4-fluoro-benzaldehyde (2 g, 12.6135 mmol) in ethanol (63 mL) was reacted with nitro methane (0.68 mL, 12.6135 mmol), 10N NaOH solution (529.7 mL, 13.2441 mmol) at 0° C. for 1 hr to afford 1.7 g of the product (67.05% yield).

Provenance & Evidence