Potassium Phosphate, Tribasic → HCID 56942894, compound

Participants

Reaction Steps

Using analogous reaction conditions as described in Example 1, 8-chloro-7-fluoro-3,4-dihydro-2H-isoquinolin-1-one (250 mg, 1.2562 mmol) was reacted with 3-iodo-4-methyl-pyridine (275.12 mg, 1.2562 mmol), 1,4-dioxane (10 mL), copper iodide (23.9 mg, 0.12562 mmol), trans-N,N′-dimethyl-cyclohexyl-1,2-diamine (60 mL, 0.3768 mmol) and potassium phosphate (665.7 mg, 3.1405 mmol) to afford the crude product. Purification by column chromatography on silica gel (40% ethylacetate in hexane) afforded 100 mg of the product (27.44% yield).

Provenance & Evidence