反应详情

Boran tri-bromide in DCM (10 mL) was added to a stirred solution of 7-methoxy-2-(4-methyl-pyridin-3-yl)-3,4-dihydro-2H-isoquinolin-1-one (35A: 1.1 g, 4.104 mmol) in DCM (20 mL) at 0° C. The resulting mixture was stirred at room temperature for 3 hours. The reaction was monitored by TLC (10% methanol in DCM). The reaction mixture was quenched with methanol and concentrated. The concentrate was partitioned between water and DCM. The organic layer was washed with brine solution, dried over Na2SO4 and concentrated. Purification by column chromatography on silica gel (3% methanol in DCM) afforded 850 mg of the product (77% yield).

1. customThe reaction mixture was quenched with methanol
2. concentrationconcentrated
3. customThe concentrate was partitioned between water and DCM
4. washThe organic layer was washed with brine solution
5. dry with materialdried over Na2SO4
6. concentrationconcentrated
7. customPurification by column chromatography on silica gel (3% methanol in DCM)