8-Hydroxyquinoline → HCID 56942895, compound

Participants

Reaction Steps

Using analogous reaction conditions as described in Example 1, 7-trifluoromethyl-2H-isoquinolin-1-one (I-29d: 0.12 g, 0.56 mmol) was reacted with 3-bromo-pyridine (0.106 g, 0.6 mmol), DMSO (2 mL), copper iodide (0.021 g, 0.12 mmol), 8-hydroxy-quinoline (0.018 g, 0.12 mmol) and potassium carbonate (0.15 g, 1.1 mmol) to afford the crude product. Purification by column chromatography on silica gel (0.5% methanol in DCM) afforded 96 mg of the product (70.58% yield).

Provenance & Evidence