Phosphorus oxide (P4O10) → HCID 66803551, compound

Participants

Reaction Steps

[2-(1-Ethyl-1H-indol-3-yl)-ethyl]-carbamic acid ethyl ester (I-38e: 4.2 g, 16.09 mmol) in POCl3 (42 mL) was reacted with P2O5 (4.56 g, 32.183 mmol) at 120° C. for 1 hr to afford the crude product. Purification by column chromatography on silica gel (70% ethylacetate in hexane) afforded 0.310 g of the product (9% yield).

Provenance & Evidence