Potassium Phosphate, Tribasic → HCID 56940973, compound

Participants

Reaction Steps

9-Ethyl-2,3,4,9-tetrahydro-b-carbolin-1-one (I-38f: 0.1 g, 0.4672 mmol) was reacted with 3-iodo-4-methyl-pyridine (0.102 g, 0.4672 mmol), 1,4-dioxane (15 mL), copper iodide (0.0089 g, 0.0467 mmol), trans-N,N′-dimethyl-cyclohexyl-1,2-diamine (0.019 g, 0.01401 mmol) and potassium phosphate (0.247 g, 1.168 mmol) to afford the crude product. Purification by column chromatography on silica gel (70% ethylacetate in hexane), followed by preparative HPLC afforded 0.019 g of the product (13.3% yield).

Provenance & Evidence