3-Bromopyridine → HCID 56940974, compound

Participants

Reaction Steps

Using analogous reaction conditions as described in Example 1, 9-ethyl-3-methyl-2,3,4,9-tetrahydro-b-carbolin-1-one (I-42d: 0.1 g, 0.4386 mmol) was reacted with 3-bromo-pyridine (0.069 g, 0.4386 mmol), 1,4-dioxane (15 mL), copper iodide (0.008 g, 0.0438 mmol), trans-N,N′-dimethyl-cyclohexyl-1,2-diamine (0.018 mg, 0.1315 mmol) and potassium phosphate (0.232 g, 1.096 mmol) to afford the crude product. Purification by column chromatography on silica gel (70% ethylacetate in hexane) afforded 46 mg of the product (34% yield).

Provenance & Evidence