HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1843949Generated: October 30, 2026
Sodium Carbonate → [2-(3-Fluoro-4-trifluoromethyl-phenyl)-ethyl]-carbamic acid ethyl ester
https://huagongshe.com/reaction/1843949
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Ethyl chloroformate | HCID 10928 | — |
| Reactant | Benzeneethanamine, 3-fluoro-4-(trifluoromethyl)- | HCID 57978173 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | [2-(3-Fluoro-4-trifluoromethyl-phenyl)-ethyl]-carbamic acid ethyl ester | HCID 89964249 | 90.4% |
Reaction Steps
2-(3-Fluoro-4-trifluoromethyl-phenyl)-ethylamine (I-47b: 2.46 g, 11.88 mmol) was reacted with ethylchloroformate (1.54 g, 14.26 mmol), 2N Na2CO3 solution (24.0 mL) and chloroform (24 mL). The resulting mixture was stirred for 30 minutes at 0° C. to afford 3.0 g of the crude product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08946260B2 |
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| Source dataset | uspto-grants-2015_02 |
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| ORD ID | ord-7eb4996350a344de8cb7947c00e77c20 |
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| Source note | uspto-grants-2015_02 |
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