HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 2-[4-(Trifluoromethoxy)phenyl]ethan-1-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 4-(Trifluoromethoxy)phenylacetonitrile | HCID 142676 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Ammonia | HCID 222 | — |
| Product | 2-[4-(Trifluoromethoxy)phenyl]ethan-1-amine | HCID 10632040 | 80% |
Reaction Steps
Using analogous conditions as described for the preparation of Intermediate I-17b, 2-(4-(trifluoromethoxy)phenyl)acetonitrile (I-51a: 3.8 g) in methanolic ammonia (50 mL) was reacted with raney nickel (7 g) and methanol (40 mL) to afford 3.1 g of the product (80% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08946260B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-41418e4f5bb74f7f9a9a0009e8cdccc6 |
| Source note | uspto-grants-2015_02 |