Phosphorus oxide (P4O10) → HCID 64282065, compound

Participants

Reaction Conditions

Reaction Steps

Using an analogous procedure and workup as described for the preparation of intermediate I-1d above, ethyl 4-(trifluoromethoxy)phenethylcarbamate (I-51c: 3.2 g, 11.5523 mmol) in POCl3 (32 mL) was reacted with P2O5 (3.27 g, 23.104 mmol). The resulting mixture was stirred at 110° C. for 1 hour to afford the crude product. Purification by column chromatography on silica gel (1.5% methanol in DCM) afforded 110 mg of the product (4.1% yield).

Provenance & Evidence