Potassium Phosphate, Tribasic → HCID 56943051, compound

Participants

Reaction Steps

Using analogous conditions as described for the preparation of Example 1A above, 7-(trifluoromethoxy)-3,4-dihydroisoquinolin-1(2H)-one (I-51d: 160 mg, 0.6896 mmol) was reacted with 3-iodo-4-methyl-pyridine (151 mg, 0.6896 mmol), 1,4-dioxane (20 mL), copper iodide (13.1 mg, 0.0689 mmol), trans-N,N′-dimethyl-cyclohexyl-1, 2-diamine (29.3 mg, 0.2068 mmol) and potassium phosphate (365 mg, 1.724 mmol) to afford the crude product. Purification by column chromatography on silica gel (40% ethylacetate in hexane), followed by preparative HPLC afforded 12 mg of the product (5.4% yield).

Provenance & Evidence