反应详情

Using analogous conditions as described for the preparation of Example 1A above, 7-(trifluoromethyl)-3,4-dihydroisoquinolin-1(2H)-one (I-4-d: 150 mg, 0.6849 mmol) was reacted with 5-bromo-1-methyl-1H-imidazole (165 mg, 1.0273 mmol), 1,4-dioxane (3 mL), copper iodide (13.01 mg, 0.0685 mmol), trans-N,N′-dimethyl-cyclohexyl-1,2-diamine (29.17 mg, 0.205 mmol) and potassium phosphate (434.6 mg, 2.05 mmol) to afford the crude product. Purification by column chromatography on silica gel (2% methanol in CHCl3) afforded 50 mg of the product (24.75% yield).

1. customas described for the preparation of Example 1A above
2. customto afford the crude product
3. customPurification by column chromatography on silica gel (2% methanol in CHCl3)