Nitromethane → 1,2-Dichloro-4-[(E)-2-nitroethenyl]benzene

Participants

Reaction Steps

Using analogous conditions and workup as described for the preparation of intermediate I-1a above, 3,4-dichlorobenzaldehyde (10 g, 74.074 mmol) in ethanol (100 mL) was reacted with nitro methane (4.12 mL, 74.074 mmol) and 10N NaOH (2.96 g in 7.4 mL of H2O, 74.074 mmol) to afford 6.2 g of the product (39% yield).

Provenance & Evidence