HuagongsheHuagongshe Chemistry Print Report · For research reference only
Indole-3-Carboxaldehyde → HCID 20109664, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Indole-3-Carboxaldehyde | HCID 10256 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 4-Methyloxybenzyl chloride | HCID 69993 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 20109664 | HCID 20109664 | 109.3% |
Reaction Steps
Using analogous procedure as those described to prepare intermediate I-38b, 1H-Indole-3-carbaldehyde (10 g, 68.96 mmol) was reacted with 1-(chloromethyl)-4-methoxybenzene (11.26 mL, 82.75 mmol) and 60% NaH (5.5 g, 137.92 mmol) in DMF (140 mL) at room temperature for 1 hour to afford 20 g of the product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08946260B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-b4599093432c4ce49f14b0885186aec9 |
| Source note | uspto-grants-2015_02 |