Nitromethane → HCID 66803492, compound

Participants

Reaction Steps

1-(4-Methoxybenzyl)-1H-indole-3-carbaldehyde (I-61a: 22 g, 83.01 mmol) was refluxed overnight with nitromethane (146 g, 2407 mmol) and ammonium acetate (3.26 g, 42.33 mmol) to afford the crude product. The reaction mass was cooled to room temperature and filtered. The solid collected was washed with water and dried under reduced pressure to afford 20 g of the product (76% yield).

Provenance & Evidence