HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → HCID 68094318, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 4-Methyloxybenzyl chloride | HCID 69993 | — |
| Reactant | HCID 59198430 | HCID 59198430 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 68094318 | HCID 68094318 | 65.21% |
Reaction Steps
8-Fluoro-2,5-dihydro-1H-pyrido[4,3-b]indol-1-one (I-64a: 0.15 g, 0.00074 mol) was reacted with 1-(chloromethyl)-4-methoxybenzene (0.14 g, 0.00092 mol), NaH (0.058 g, 0.058 mol) and DMF (10 mL) to afford the crude product. Purification by column chromatography on silica gel (1.5% methanol in DCM) afforded 0.15 g of the product (65.21% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08946260B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-5484ef55c07645bca02de40d23770035 |
| Source note | uspto-grants-2015_02 |