7-Nitro-3,4-dihydroisoquinolin-1(2H)-one → 7-Amino-1,2,3,4-tetrahydroisoquinolin-1-one

Participants

Reaction Steps

Using analogous reaction conditions, work up and purification as described for the preparation of intermediate I-24c above, 7-Nitro-3,4-dihydro-2H-isoquinolin-1-one (I-24a: 2.5 g, 0.013 mol) in methanol (50 mL) was reacted with 10% Pd—C (0.5 g) to afford the crude product, which was washed with n-hexane to afford 1.8 g of the product (85.71% yield).

Provenance & Evidence