Potassium Phosphate, Tribasic → HCID 56941126, compound

Participants

Reaction Steps

7,8-Dihydrothiazolo[4,5-h]isoquinolin-9(6H)-one (I-66c: 0.13 g, 0.0006 mol) was reacted with 3-iodo-4-methylpyridine (0.15 g, 0.0007 mol), copper iodide (0.036 g, 0.00019 mol), trans-N,N′-dimethyl-cyclohexyl-1,2-diamine (0.027 g, 0.00019 mol) and potassium phosphate (0.45 g, 0.0015 mol) in 1,4-dioxane (10 mL) to afford the crude product. Purification by column chromatography on silica gel (2% methanol in DCM) afforded 36 mg of the product (20.2% yield).

Provenance & Evidence