HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methoxybenzylamine → 3-(2-hydroxyethyl)-N-(4-methoxybenzyl)isonicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methoxybenzylamine | HCID 75452 | — |
| Reactant | 3,4-dihydro-1H-pyrano[4,3-c]pyridin-1-one | HCID 89963837 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-(2-hydroxyethyl)-N-(4-methoxybenzyl)isonicotinamide | HCID 89964514 | — |
Reaction Steps
3,4-Dihydro-1H-pyrano[4,3-c]pyridin-1-one (I-67e: 100 mg, (0.666 mmol) in THF (1 mL) was refluxed with p-methoxybenzylamine (0.9 mL, 6.66 mmol) to afford 220 mg of the crude product. LCMS: 95.54%, m/z=287.1 (M+1)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08946260B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-90d58b1865bc40d894a309ab5dac9c52 |
| Source note | uspto-grants-2015_02 |